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KMID : 0861020120270040001
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Korea Journal of Herbology
2012 Volume.27 No. 4 p.1 ~ p.7
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Effects of KOB, a polyherbal medicine for allergic rhinitis and its main herb, Astragali Radix on allergic responses in OVA-induced Allergic rhinitis mice
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Kang Seok-Yong
Hong Seung-Ug
Park Yong-Kee
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Abstract
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Objectives: In this study, we investigated the effect of KOB, a polyherbal medicine for allergic rhinitis and its main herb, Astragali Radix on allergic responses in ovalbumin (OVA)-induced Allergic rhinitis(AR) mice.
Methods: Sprague Dawley (SD)-rats were orally administrated with KOB (500 ㎎/㎏), Astragali Radix water extract (ARW, 100 ㎎/㎏) or anti-histamine drug, dosodium cromoglycate (50 ㎎/㎏) as a reference drug, and then intraperitoneally injected with compound 48/80 (8 ㎎/㎏). Rats were measured the mortality and serum levels of histamine. BALB/c mice were orally administrated with KOB (500 ㎎/㎏), ARW (100 ㎎/㎏) or anti-histamine drug, Ketotifen (10 ㎎/㎏) as a reference drug, followed by sensitization and challenge of OVA. Mice were measured the serum levels of histamine and IgE, and observed histopathological changes of nasa mucosa H&E staining.
Results: KOB and ARW significantly decreased the mortality and the serum levels of histamine in compound 48/80-induced anaphylatic rats. KOB and ARW also decreased the serum levels of histamine and IgE in OVA-induced AR mice, and inhibited histopathological changes of nasal mucosa with inflammation and the eosinophils infilteration.
Conclusions: These data suggest that KOB has a strong anti-allergic effect through the inhibitory property of Astragali Radix, the main component of KOB against allergic responses in allergic rhinitis.
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KEYWORD
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Astragali Radix, KOB, anti-allergic effect, Allergic rhinitis, anaphylaxis
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